1g9p: Difference between revisions

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[[Image:1g9p.jpg|left|200px]]<br /><applet load="1g9p" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1g9p.jpg|left|200px]]<br /><applet load="1g9p" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1g9p" />

'''SOLUTION STRUCTURE OF THE INSECTICIDAL CALCIUM CHANNEL BLOCKER OMEGA-ATRACOTOXIN-HV2A'''<br />

==Overview==

We have isolated a novel family of insect-selective neurotoxins that, appear to be the most potent blockers of insect voltage-gated calcium, channels reported to date. These toxins display exceptional phylogenetic, specificity, with at least a 10,000-fold preference for insect versus, vertebrate calcium channels. The structure of one of the toxins reveals a, highly structured, disulfide-rich core and a structurally disordered, C-terminal extension that is essential for channel blocking activity. Weak, structural/functional homology with omega-agatoxin-IVA/B, the prototypic, inhibitor of vertebrate P-type calcium channels, suggests that these two, toxin families might share a similar mechanism of action despite their, vastly different phylogenetic specificities.

We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.

==About this Structure==

1G9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1G9P OCA].

1G9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G9P OCA].

==Reference==

Line 13:

[[Category: Hadronyche versuta]]

[[Category: Single protein]]

[[Category: King, G.F.]]

[[Category: King, G F.]]

[[Category: Wang, X.H.]]

[[Category: Wang, X H.]]

[[Category: cystine knot]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 15~~:51:~~34 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:47:42 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1g9p.jpg|left|200px]]<br /><applet load="1g9p" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1g9p.jpg|left|200px]]<br /><applet load="1g9p" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1g9p" />
 '''SOLUTION STRUCTURE OF THE INSECTICIDAL CALCIUM CHANNEL BLOCKER OMEGA-ATRACOTOXIN-HV2A'''<br />
 ==Overview==
-We have isolated a novel family of insect-selective neurotoxins that, appear to be the most potent blockers of insect voltage-gated calcium, channels reported to date. These toxins display exceptional phylogenetic, specificity, with at least a 10,000-fold preference for insect versus, vertebrate calcium channels. The structure of one of the toxins reveals a, highly structured, disulfide-rich core and a structurally disordered, C-terminal extension that is essential for channel blocking activity. Weak, structural/functional homology with omega-agatoxin-IVA/B, the prototypic, inhibitor of vertebrate P-type calcium channels, suggests that these two, toxin families might share a similar mechanism of action despite their, vastly different phylogenetic specificities.
+We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with omega-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.
 ==About this Structure==
-G9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1G9P OCA].
+G9P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hadronyche_versuta Hadronyche versuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G9P OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Hadronyche versuta]]
 [[Category: Single protein]]
-[[Category: King, G.F.]]
+[[Category: King, G F.]]
-[[Category: Wang, X.H.]]
+[[Category: Wang, X H.]]
 [[Category: cystine knot]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:51:34 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:47:42 2008''