1twx: Difference between revisions

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{{Seed}}
[[Image:1twx.png|left|200px]]
[[Image:1twx.png|left|200px]]


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{{STRUCTURE_1twx|  PDB=1twx  |  SCENE=  }}  
{{STRUCTURE_1twx|  PDB=1twx  |  SCENE=  }}  


===Crystal structure of the thrombin mutant D221A/D222K===
===Crystal structure of the thrombin mutant D221A/D222K===


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{{ABSTRACT_PUBMED_15572256}}
{{ABSTRACT_PUBMED_15572256}}


==Disease==
==About this Structure==
Known disease associated with this structure: Dysprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hyperprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]], Hypoprothrombinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176930 176930]]
[[1twx]] is a 3 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TWX OCA].


==About this Structure==
==See Also==
1TWX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TWX OCA].
*[[Hirudin|Hirudin]]
*[[Thrombin|Thrombin]]


==Reference==
==Reference==
<ref group="xtra">PMID:15572256</ref><references group="xtra"/>
<ref group="xtra">PMID:015572256</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
Line 35: Line 24:
[[Category: Tulinsky, A.]]
[[Category: Tulinsky, A.]]
[[Category: Zhang, E.]]
[[Category: Zhang, E.]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Thrombin]]
[[Category: Thrombin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:01:39 2009''

Revision as of 06:02, 27 July 2012

File:1twx.png

Template:STRUCTURE 1twx

Crystal structure of the thrombin mutant D221A/D222K

Template:ABSTRACT PUBMED 15572256

About this Structure

1twx is a 3 chain structure of Hirudin and Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Pineda AO, Zhang E, Guinto ER, Savvides SN, Tulinsky A, Di Cera E. Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form. Biophys Chem. 2004 Dec 20;112(2-3):253-6. PMID:15572256 doi:https://dx.doi.org/10.1016/j.bpc.2004.07.027

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