1gcn: Difference between revisions

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[[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1gcn, resolution 3.0Å" />

'''X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING'''<br />

==Overview==

X-ray analysis of the pancreatic hormone glucagon shows that in crystals, the polypeptide adopts a mainly helical conformation, which is stabilised, by hydrophobic interactions between molecules related by threefold, symmetry. A model is presented in which the glucagon molecule exists in, dilute solutions as an equilibrium population of conformers with little, retention of conformers with little retention of structure, and in which, the helical conformation is stablised by hydrophobic interactions either, as an oligomer or as a complex with the receptor.

X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.

==About this Structure==

1GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA].

1GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Sus scrofa]]

[[Category: Blundell, T.L.]]

[[Category: Blundell, T L.]]

[[Category: Dockerill, S.]]

[[Category: Sasaki, K.]]

[[Category: Tickle, I.J.]]

[[Category: Tickle, I J.]]

[[Category: hormone]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 15~~:56:~~49 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:48:42 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1gcn.gif|left|200px]]<br /><applet load="1gcn" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1gcn, resolution 3.0&Aring;" />
 '''X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING'''<br />
 ==Overview==
-X-ray analysis of the pancreatic hormone glucagon shows that in crystals, the polypeptide adopts a mainly helical conformation, which is stabilised, by hydrophobic interactions between molecules related by threefold, symmetry. A model is presented in which the glucagon molecule exists in, dilute solutions as an equilibrium population of conformers with little, retention of conformers with little retention of structure, and in which, the helical conformation is stablised by hydrophobic interactions either, as an oligomer or as a complex with the receptor.
+X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.
 ==About this Structure==
-GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA].
+GCN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCN OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Sus scrofa]]
-[[Category: Blundell, T.L.]]
+[[Category: Blundell, T L.]]
 [[Category: Dockerill, S.]]
 [[Category: Sasaki, K.]]
-[[Category: Tickle, I.J.]]
+[[Category: Tickle, I J.]]
 [[Category: hormone]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:56:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:48:42 2008''