3d1y: Difference between revisions
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[[Image:3d1y.png|left|200px]] | [[Image:3d1y.png|left|200px]] | ||
{{STRUCTURE_3d1y| PDB=3d1y | SCENE= }} | {{STRUCTURE_3d1y| PDB=3d1y | SCENE= }} | ||
===Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA=== | ===Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA=== | ||
{{ABSTRACT_PUBMED_18597780}} | {{ABSTRACT_PUBMED_18597780}} | ||
==About this Structure== | ==About this Structure== | ||
[[3d1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1Y OCA]. | [[3d1y]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1Y OCA]. | ||
==See Also== | ==See Also== | ||
*[[Saquinavir]] | *[[Saquinavir|Saquinavir]] | ||
*[[Virus protease|Virus protease]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:018597780</ref><ref group="xtra">PMID:016962136</ref><ref group="xtra">PMID:016277992</ref><references group="xtra"/> | ||
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
| Line 34: | Line 24: | ||
[[Category: Capsid maturation]] | [[Category: Capsid maturation]] | ||
[[Category: Capsid protein]] | [[Category: Capsid protein]] | ||
[[Category: Drug resistance]] | [[Category: Drug resistance]] | ||
[[Category: Flap mutant]] | [[Category: Flap mutant]] | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: I54v]] | [[Category: I54v]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
Revision as of 06:24, 27 July 2012
Crystal structure of HIV-1 mutant I54V and inhibitor SAQUINA
Template:ABSTRACT PUBMED 18597780
About this Structure
3d1y is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
See Also
Reference
- Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
- Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
- Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095
