4ago: Difference between revisions

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[[Image:4ago.png|left|200px]]
[[Image:4ago.png|left|200px]]


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{{STRUCTURE_4ago|  PDB=4ago  |  SCENE=  }}  
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===Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174===
===Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174===


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{{ABSTRACT_PUBMED_22439615}}
{{ABSTRACT_PUBMED_22439615}}


==About this Structure==
==About this Structure==
[[4ago]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGO OCA].  
[[4ago]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGO OCA].  
 
==See Also==
*[[P53|P53]]


==Reference==
==Reference==

Revision as of 06:47, 27 July 2012

File:4ago.png

Template:STRUCTURE 4ago

Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174

Template:ABSTRACT PUBMED 22439615

About this Structure

4ago is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Wilcken R, Liu X, Zimmermann MO, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53. J Am Chem Soc. 2012 Apr 18;134(15):6810-8. Epub 2012 Apr 5. PMID:22439615 doi:10.1021/ja301056a
  2. Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

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