2r4f: Difference between revisions
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[[Image:2r4f.png|left|200px]] | [[Image:2r4f.png|left|200px]] | ||
{{STRUCTURE_2r4f| PDB=2r4f | SCENE= }} | {{STRUCTURE_2r4f| PDB=2r4f | SCENE= }} | ||
===Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors=== | ===Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors=== | ||
{{ABSTRACT_PUBMED_18072721}} | {{ABSTRACT_PUBMED_18072721}} | ||
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==See Also== | ==See Also== | ||
*[[HMG-CoA Reductase]] | *[[HMG-CoA Reductase|HMG-CoA Reductase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:018072721</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Finzel, B C.]] | [[Category: Finzel, B C.]] | ||
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[[Category: Pavlovsky, A.]] | [[Category: Pavlovsky, A.]] | ||
[[Category: Pfefferkorn, J A.]] | [[Category: Pfefferkorn, J A.]] | ||
[[Category: Biocynthesis]] | [[Category: Biocynthesis]] | ||
[[Category: Cholesterol]] | [[Category: Cholesterol]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Peroxisome]] | [[Category: Peroxisome]] | ||
[[Category: Statin]] | [[Category: Statin]] | ||
[[Category: Steroid biosynthesis]] | [[Category: Steroid biosynthesis]] | ||
[[Category: Sterol biosynthesis]] | [[Category: Sterol biosynthesis]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
Revision as of 06:51, 27 July 2012
Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
Template:ABSTRACT PUBMED 18072721
About this Structure
2r4f is a 4 chain structure of HMG-CoA Reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r
