1ghq: Difference between revisions

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==Overview==

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B, lymphocyte activation by bridging the innate and adaptive immune systems., CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein, 350/220. We describe the x-ray structure of this CR2 domain in complex, with C3d at 2.0 angstroms. The structure reveals extensive main chain, interactions between C3d and only one short consensus repeat (SCR) of CR2, and substantial SCR side-side packing. These results provide a detailed, understanding of receptor-ligand interactions in this protein family and, reveal potential target sites for molecular drug design.

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Chen, X.S.]]

[[Category: Chen, X S.]]

[[Category: Guthridge, J.M.]]

[[Category: Guthridge, J M.]]

[[Category: Holers, V.M.]]

[[Category: Holers, V M.]]

[[Category: Li, D.]]

[[Category: Szakonyi, G.]]

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[[Category: cr2]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B, lymphocyte activation by bridging the innate and adaptive immune systems., CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein, 350/220. We describe the x-ray structure of this CR2 domain in complex, with C3d at 2.0 angstroms. The structure reveals extensive main chain, interactions between C3d and only one short consensus repeat (SCR) of CR2, and substantial SCR side-side packing. These results provide a detailed, understanding of receptor-ligand interactions in this protein family and, reveal potential target sites for molecular drug design.
+Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Chen, X.S.]]
+[[Category: Chen, X S.]]
-[[Category: Guthridge, J.M.]]
+[[Category: Guthridge, J M.]]
-[[Category: Holers, V.M.]]
+[[Category: Holers, V M.]]
 [[Category: Li, D.]]
 [[Category: Szakonyi, G.]]
@@ Line 26: / Line 26: @@
 [[Category: cr2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:53:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:50:13 2008''