1gpf: Difference between revisions

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==Overview==

Several brominated tyrosine derived compounds, psammaplins A (1), K (2), and L (3) as well as bisaprasin (4) were isolated from the Fijian marine, sponge Aplysinella rhax during a bioassay guided isolation protocol. Their, structures were determined using NMR and MS techniques. Psammaplin A was, found to moderately inhibit chitinase B from Serratia marcescens, the mode, of inhibition being non-competitive. Crystallographic studies suggest that, a disordered psammaplin A molecule is bound near the active site., Interestingly, psammaplin A was found to be a potent antifungal agent.

Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.

==About this Structure==

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[[Category: Serratia marcescens]]

[[Category: Single protein]]

[[Category: Aalten, D.M.Van.]]

[[Category: Aalten, D M.Van.]]

[[Category: Komander, D.]]

[[Category: SO4]]

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[[Category: inhibitor psammaplin]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:52:34 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Several brominated tyrosine derived compounds, psammaplins A (1), K (2), and L (3) as well as bisaprasin (4) were isolated from the Fijian marine, sponge Aplysinella rhax during a bioassay guided isolation protocol. Their, structures were determined using NMR and MS techniques. Psammaplin A was, found to moderately inhibit chitinase B from Serratia marcescens, the mode, of inhibition being non-competitive. Crystallographic studies suggest that, a disordered psammaplin A molecule is bound near the active site., Interestingly, psammaplin A was found to be a potent antifungal agent.
+Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Serratia marcescens]]
 [[Category: Single protein]]
-[[Category: Aalten, D.M.Van.]]
+[[Category: Aalten, D M.Van.]]
 [[Category: Komander, D.]]
 [[Category: SO4]]
@@ Line 21: / Line 21: @@
 [[Category: inhibitor psammaplin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:41:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:52:34 2008''