2flr: Difference between revisions

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{{Seed}}
[[Image:2flr.png|left|200px]]
[[Image:2flr.png|left|200px]]


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{{STRUCTURE_2flr|  PDB=2flr  |  SCENE=  }}  
{{STRUCTURE_2flr|  PDB=2flr  |  SCENE=  }}  


===Novel 5-Azaindole Factor VIIa Inhibitors===
===Novel 5-Azaindole Factor VIIa Inhibitors===


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{{ABSTRACT_PUBMED_16621549}}
{{ABSTRACT_PUBMED_16621549}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]
[[2flr]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLR OCA].


==About this Structure==
==See Also==
2FLR is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLR OCA].
*[[Factor VIIa|Factor VIIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:16621549</ref><references group="xtra"/>
<ref group="xtra">PMID:016621549</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 44: Line 32:
[[Category: Yu, C.]]
[[Category: Yu, C.]]
[[Category: 5-azaindole inhibitor]]
[[Category: 5-azaindole inhibitor]]
[[Category: Hydrolase-blood clotting complex]]
[[Category: S1 site]]
[[Category: S1 site]]
[[Category: Short hydrogen bond]]
[[Category: Short hydrogen bond]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:48:34 2009''

Revision as of 09:26, 27 July 2012

File:2flr.png

Template:STRUCTURE 2flr

Novel 5-Azaindole Factor VIIa Inhibitors

Template:ABSTRACT PUBMED 16621549

About this Structure

2flr is a 3 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB. Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18. PMID:16621549 doi:10.1016/j.bmcl.2006.03.049

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