1gv4: Difference between revisions

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==Overview==

Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, C-terminal beta-hairpin loop, which may be related to its apoptogenic, functions.

Mitochondria play a key role in apoptosis due to their capacity to release potentially lethal proteins. One of these latent death factors is cytochrome c, which can stimulate the proteolytic activation of caspase zymogens. Another important protein is apoptosis-inducing factor (AIF), a flavoprotein that can stimulate a caspase-independent cell-death pathway required for early embryonic morphogenesis. Here, we report the crystal structure of mouse AIF at 2.0 A. Its active site structure and redox properties suggest that AIF functions as an electron transferase with a mechanism similar to that of the bacterial ferredoxin reductases, its closest evolutionary homologs. However, AIF structurally differs from these proteins in some essential features, including a long insertion in a C-terminal beta-hairpin loop, which may be related to its apoptogenic functions.

==About this Structure==

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[[Category: Mus musculus]]

[[Category: Single protein]]

[[Category: Alzari, P.M.]]

[[Category: Alzari, P M.]]

[[Category: Mate, M.J.]]

[[Category: Mate, M J.]]

[[Category: FAD]]

[[Category: apoptosi]]

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[[Category: oxidoreductase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:19 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Mitochondria play a key role in apoptosis due to their capacity to release, potentially lethal proteins. One of these latent death factors is, cytochrome c, which can stimulate the proteolytic activation of caspase, zymogens. Another important protein is apoptosis-inducing factor (AIF), a, flavoprotein that can stimulate a caspase-independent cell-death pathway, required for early embryonic morphogenesis. Here, we report the crystal, structure of mouse AIF at 2.0 A. Its active site structure and redox, properties suggest that AIF functions as an electron transferase with a, mechanism similar to that of the bacterial ferredoxin reductases, its, closest evolutionary homologs. However, AIF structurally differs from, these proteins in some essential features, including a long insertion in a, C-terminal beta-hairpin loop, which may be related to its apoptogenic, functions.
+Mitochondria play a key role in apoptosis due to their capacity to release potentially lethal proteins. One of these latent death factors is cytochrome c, which can stimulate the proteolytic activation of caspase zymogens. Another important protein is apoptosis-inducing factor (AIF), a flavoprotein that can stimulate a caspase-independent cell-death pathway required for early embryonic morphogenesis. Here, we report the crystal structure of mouse AIF at 2.0 A. Its active site structure and redox properties suggest that AIF functions as an electron transferase with a mechanism similar to that of the bacterial ferredoxin reductases, its closest evolutionary homologs. However, AIF structurally differs from these proteins in some essential features, including a long insertion in a C-terminal beta-hairpin loop, which may be related to its apoptogenic functions.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Single protein]]
-[[Category: Alzari, P.M.]]
+[[Category: Alzari, P M.]]
-[[Category: Mate, M.J.]]
+[[Category: Mate, M J.]]
 [[Category: FAD]]
 [[Category: apoptosi]]
@@ Line 22: / Line 22: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:42:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:19 2008''