1gya: Difference between revisions

Line 1:

[[Image:1gya.gif|left|200px]]<br />

[[Image:1gya.gif|left|200px]]<br /><applet load="1gya" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1gya" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1gya" />

'''N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2'''<br />

==Overview==

The adhesion domain of human CD2 bears a single N-linked carbohydrate. The, solution structure of a fragment of CD2 containing the covalently bound, high-mannose N-glycan [-(N-acetylglucosamine)2-(mannose)5-8] was solved by, nuclear magnetic resonance. The stem and two of three branches of the, carbohydrate structure are well defined and the mobility of proximal, glycan residues is restricted. Mutagenesis of all residues in the vicinity, of the glycan suggests that the glycan is not a component of the CD2-CD58, interface; rather, the carbohydrate stabilizes the protein fold by, counterbalancing an unfavorable clustering of five positive charges, centered about lysine-61 of CD2.

The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution structure of a fragment of CD2 containing the covalently bound high-mannose N-glycan [-(N-acetylglucosamine)2-(mannose)5-8] was solved by nuclear magnetic resonance. The stem and two of three branches of the carbohydrate structure are well defined and the mobility of proximal glycan residues is restricted. Mutagenesis of all residues in the vicinity of the glycan suggests that the glycan is not a component of the CD2-CD58 interface; rather, the carbohydrate stabilizes the protein fold by counterbalancing an unfavorable clustering of five positive charges centered about lysine-61 of CD2.

==About this Structure==

1GYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].

1GYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].

==Reference==

Line 14:

Line 13:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Choi, J.S.]]

[[Category: Choi, J S.]]

[[Category: Wagner, G.]]

[[Category: Wyss, D.F.]]

[[Category: Wyss, D F.]]

[[Category: cell surface adhesion receptor]]

[[Category: immunoglobulin superfamily v-set domain]]

[[Category: t lymphocyte adhesion glycoprotein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 17:10:~~09 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:18 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1gya.gif|left|200px]]<br />
+[[Image:1gya.gif|left|200px]]<br /><applet load="1gya" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1gya" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1gya" />
 '''N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2'''<br />
 ==Overview==
-The adhesion domain of human CD2 bears a single N-linked carbohydrate. The, solution structure of a fragment of CD2 containing the covalently bound, high-mannose N-glycan [-(N-acetylglucosamine)2-(mannose)5-8] was solved by, nuclear magnetic resonance. The stem and two of three branches of the, carbohydrate structure are well defined and the mobility of proximal, glycan residues is restricted. Mutagenesis of all residues in the vicinity, of the glycan suggests that the glycan is not a component of the CD2-CD58, interface; rather, the carbohydrate stabilizes the protein fold by, counterbalancing an unfavorable clustering of five positive charges, centered about lysine-61 of CD2.
+The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution structure of a fragment of CD2 containing the covalently bound high-mannose N-glycan [-(N-acetylglucosamine)2-(mannose)5-8] was solved by nuclear magnetic resonance. The stem and two of three branches of the carbohydrate structure are well defined and the mobility of proximal glycan residues is restricted. Mutagenesis of all residues in the vicinity of the glycan suggests that the glycan is not a component of the CD2-CD58 interface; rather, the carbohydrate stabilizes the protein fold by counterbalancing an unfavorable clustering of five positive charges centered about lysine-61 of CD2.
 ==About this Structure==
-GYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].
+GYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYA OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Choi, J.S.]]
+[[Category: Choi, J S.]]
 [[Category: Wagner, G.]]
-[[Category: Wyss, D.F.]]
+[[Category: Wyss, D F.]]
 [[Category: cell surface adhesion receptor]]
 [[Category: immunoglobulin superfamily v-set domain]]
 [[Category: t lymphocyte adhesion glycoprotein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:10:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:18 2008''