1xkk: Difference between revisions

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[[Image:1xkk.png|left|200px]]
[[Image:1xkk.png|left|200px]]


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{{STRUCTURE_1xkk|  PDB=1xkk  |  SCENE=  }}  
{{STRUCTURE_1xkk|  PDB=1xkk  |  SCENE=  }}  


===EGFR kinase domain complexed with a quinazoline inhibitor- GW572016===
===EGFR kinase domain complexed with a quinazoline inhibitor- GW572016===


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{{ABSTRACT_PUBMED_15374980}}


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==See Also==
==See Also==
*[[Epidermal Growth Factor Receptor]]
*[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]]


==Reference==
==Reference==
<ref group="xtra">PMID:15374980</ref><references group="xtra"/>
<ref group="xtra">PMID:015374980</ref><references group="xtra"/>
[[Category: Epidermal Growth Factor Receptor]]
[[Category: Epidermal Growth Factor Receptor]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 10:52, 27 July 2012

File:1xkk.png

Template:STRUCTURE 1xkk

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

Template:ABSTRACT PUBMED 15374980

About this Structure

1xkk is a 1 chain structure of Epidermal Growth Factor Receptor with sequence from Homo sapiens. The June 2010 RCSB PDB Molecule of the Month feature on Epidermal Growth Factor Receptor by David Goodsell is 10.2210/rcsb_pdb/mom_2010_6. Full crystallographic information is available from OCA.

See Also

Reference

  1. Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 2004 Sep 15;64(18):6652-9. PMID:15374980 doi:10.1158/0008-5472.CAN-04-1168

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