1h2p: Difference between revisions
New page: left|200px<br /> <applet load="1h2p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h2p, resolution 2.8Å" /> '''HUMAN CD55 DOMAINS 3... |
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'''HUMAN CD55 DOMAINS 3 & 4'''<br /> | '''HUMAN CD55 DOMAINS 3 & 4'''<br /> | ||
==Overview== | ==Overview== | ||
Decay-accelerating factor (CD55), a regulator of the alternative and | Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1H2P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2P OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Billington, J.]] | [[Category: Billington, J.]] | ||
[[Category: Chaudhry, Y.]] | [[Category: Chaudhry, Y.]] | ||
[[Category: Evans, D | [[Category: Evans, D J.]] | ||
[[Category: Goodfellow, I.]] | [[Category: Goodfellow, I.]] | ||
[[Category: Lea, S | [[Category: Lea, S M.]] | ||
[[Category: Spiller, B.]] | [[Category: Spiller, B.]] | ||
[[Category: Williams, P.]] | [[Category: Williams, P.]] | ||
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[[Category: ligand for cd97]] | [[Category: ligand for cd97]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:56:42 2008'' | ||
Revision as of 10:56, 21 February 2008
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HUMAN CD55 DOMAINS 3 & 4
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1H2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389
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