2of4: Difference between revisions

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{{Seed}}
[[Image:2of4.png|left|200px]]
[[Image:2of4.png|left|200px]]


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{{STRUCTURE_2of4|  PDB=2of4  |  SCENE=  }}  
{{STRUCTURE_2of4|  PDB=2of4  |  SCENE=  }}  


===crystal structure of furanopyrimidine 1 bound to lck===
===crystal structure of furanopyrimidine 1 bound to lck===


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{{ABSTRACT_PUBMED_17276681}}
{{ABSTRACT_PUBMED_17276681}}


==Disease==
==About this Structure==
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
[[2of4]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] and [[Tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF4 OCA].


==About this Structure==
==See Also==
2OF4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF4 OCA].
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]
*[[Tyrosine kinase|Tyrosine kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:17276681</ref><references group="xtra"/>
<ref group="xtra">PMID:017276681</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Kinase domain]]
[[Category: Kinase domain]]
[[Category: Lck]]
[[Category: Lck]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:26:30 2009''

Revision as of 11:48, 27 July 2012

File:2of4.png

Template:STRUCTURE 2of4

crystal structure of furanopyrimidine 1 bound to lck

Template:ABSTRACT PUBMED 17276681

About this Structure

2of4 is a 1 chain structure of Proto-oncogene tyrosine-protein kinase and Tyrosine kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, DiMauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X. Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681 doi:10.1016/j.bmcl.2007.01.048

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