1ha1: Difference between revisions

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[[Image:1ha1.gif|left|200px]]<br />

[[Image:1ha1.gif|left|200px]]<br /><applet load="1ha1" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ha1" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ha1, resolution 1.75Å" />

'''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''<br />

==Overview==

Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic, nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA, into hnRNP particles, transport of poly A+ mRNA from the nucleus to the, cytoplasm and may modulate splice site selection. The crystal structure of, A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs), connected by a flexible linker. Both RBDs are structurally homologous to, the U1A(RBD1), and have their RNA binding platforms oriented in an, anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding, platforms suggests mechanisms for RNA condensation and ways of bringing, together distant RNA sequences for RNA metabolism such as splicing or, transport.

Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport.

==About this Structure==

1HA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].

1HA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].

==Reference==

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[[Category: Rice, L.]]

[[Category: Shamoo, Y.]]

[[Category: Steitz, T.A.]]

[[Category: Steitz, T A.]]

[[Category: Williams, K.R.]]

[[Category: Williams, K R.]]

[[Category: hnrnp]]

[[Category: nuclear protein]]

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[[Category: rrm]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 17:14:~~37 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:03 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ha1.gif|left|200px]]<br />
+[[Image:1ha1.gif|left|200px]]<br /><applet load="1ha1" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ha1" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ha1, resolution 1.75&Aring;" />
 '''HNRNP A1 (RBD1,2) FROM HOMO SAPIENS'''<br />
 ==Overview==
-Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic, nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA, into hnRNP particles, transport of poly A+ mRNA from the nucleus to the, cytoplasm and may modulate splice site selection. The crystal structure of, A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs), connected by a flexible linker. Both RBDs are structurally homologous to, the U1A(RBD1), and have their RNA binding platforms oriented in an, anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding, platforms suggests mechanisms for RNA condensation and ways of bringing, together distant RNA sequences for RNA metabolism such as splicing or, transport.
+Heterogeneous ribonucleoprotein A1 (hnRNP A1) is an abundant eukaryotic nuclear RNA binding protein. A1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm and may modulate splice site selection. The crystal structure of A1(RBD1,2) reveals two independently-folded RNA binding domains (RBDs) connected by a flexible linker. Both RBDs are structurally homologous to the U1A(RBD1), and have their RNA binding platforms oriented in an anti-parallel fashion. The anti-parallel arrangement of the A1 RNA binding platforms suggests mechanisms for RNA condensation and ways of bringing together distant RNA sequences for RNA metabolism such as splicing or transport.
 ==About this Structure==
-HA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].
+HA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Rice, L.]]
 [[Category: Shamoo, Y.]]
-[[Category: Steitz, T.A.]]
+[[Category: Steitz, T A.]]
-[[Category: Williams, K.R.]]
+[[Category: Williams, K R.]]
 [[Category: hnrnp]]
 [[Category: nuclear protein]]
@@ Line 27: / Line 26: @@
 [[Category: rrm]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:14:37 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:59:03 2008''