3dyg: Difference between revisions

Revision as of 15:55, 27 July 2012

3dyg is a 2 chain structure of Farnesyl diphosphate synthase with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.

Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J Am Chem Soc. 2009 Apr 15;131(14):5153-62. PMID:19309137 doi:10.1021/ja808285e

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 [[Image:3dyg.png|left|200px]]
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 ===T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461===
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