1hq8: Difference between revisions

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[[Image:1hq8.gif|left|200px]]<br /><applet load="1hq8" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1hq8.gif|left|200px]]<br /><applet load="1hq8" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1hq8, resolution 1.95Å" />

'''CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A'''<br />

==Overview==

NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory, molecule that is found on natural killer cells,T cells and activated, macrophages.The natural ligands for murine NKG2D are distant major, histocompatibility complex homologs, retinoic acid early transcript (Rae1), and H-60 minor histocompatibility antigen. The crystal structure of the, extracellular region of murine NKG2D reveals close homology with other, C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer, receptors, as well as their surface topography and electrostatic, properties.The NKG2D structure provides the first structural insights into, the role and ligand specificity of this stimulatory receptor in the innate, and adaptive immune system.

NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.

==About this Structure==

1HQ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].

1HQ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Bauer, S.]]

[[Category: Busch, D.H.]]

[[Category: Busch, D H.]]

[[Category: Rudolph, M.G.]]

[[Category: Rudolph, M G.]]

[[Category: Teyton, L.]]

[[Category: Villmow, B.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: Wolan, D.W.]]

[[Category: Wolan, D W.]]

[[Category: cis-proline]]

[[Category: homodimer]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 16~~:44:~~23 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:03:48 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1hq8.gif|left|200px]]<br /><applet load="1hq8" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1hq8.gif|left|200px]]<br /><applet load="1hq8" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1hq8, resolution 1.95&Aring;" />
 '''CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A'''<br />
 ==Overview==
-NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory, molecule that is found on natural killer cells,T cells and activated, macrophages.The natural ligands for murine NKG2D are distant major, histocompatibility complex homologs, retinoic acid early transcript (Rae1), and H-60 minor histocompatibility antigen. The crystal structure of the, extracellular region of murine NKG2D reveals close homology with other, C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer, receptors, as well as their surface topography and electrostatic, properties.The NKG2D structure provides the first structural insights into, the role and ligand specificity of this stimulatory receptor in the innate, and adaptive immune system.
+NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.
 ==About this Structure==
-HQ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].
+HQ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Bauer, S.]]
-[[Category: Busch, D.H.]]
+[[Category: Busch, D H.]]
-[[Category: Rudolph, M.G.]]
+[[Category: Rudolph, M G.]]
 [[Category: Teyton, L.]]
 [[Category: Villmow, B.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
-[[Category: Wolan, D.W.]]
+[[Category: Wolan, D W.]]
 [[Category: cis-proline]]
 [[Category: homodimer]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:44:23 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:03:48 2008''