Factor Xa: Difference between revisions
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[[Image:Coagulation full.svg.png|thumb| | [[Image:Coagulation full.svg.png|thumb|500px|The coagulation cascade.]] | ||
==Introduction== | ==Introduction== | ||
'''Factor X''' is a vitamin K-dependent [http://en.wikipedia.org/wiki/Glycoprotein glycoprotein] that is synthesized in the liver. [http://en.wikipedia.org/wiki/Zymogen Zymogen] factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to '''factor Xa''' by cleavage of the activation peptide. This reaction is catalyzed by [http://en.wikipedia.org/wiki/Factor_VIIa factor VIIa]-[http://en.wikipedia.org/wiki/Tissue_factor tissue factor] (extrinsic Xase complex) and [http://en.wikipedia.org/wiki/Factor_ixa factor IXa]-[http://en.wikipedia.org/wiki/Factor_viiia factor VIIIa] (intrinsic Xase complex).<ref name="Greer">Greer, John (2008). ''Wintrobe's Clinical Hematology'', p. 545-546. Lippincott Williams & Wilkins. ISBN 0781765072.</ref> | '''Factor X''' is a vitamin K-dependent [http://en.wikipedia.org/wiki/Glycoprotein glycoprotein] that is synthesized in the liver. [http://en.wikipedia.org/wiki/Zymogen Zymogen] factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to '''factor Xa''' by cleavage of the activation peptide. This reaction is catalyzed by [http://en.wikipedia.org/wiki/Factor_VIIa factor VIIa]-[http://en.wikipedia.org/wiki/Tissue_factor tissue factor] (extrinsic Xase complex) and [http://en.wikipedia.org/wiki/Factor_ixa factor IXa]-[http://en.wikipedia.org/wiki/Factor_viiia factor VIIIa] (intrinsic Xase complex).<ref name="Greer">Greer, John (2008). ''Wintrobe's Clinical Hematology'', p. 545-546. Lippincott Williams & Wilkins. ISBN 0781765072.</ref> | ||
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[[1kig]] - bFX heavy chain catalytic domain + light chain EGF-like domain + anticoagulant peptide<br /> | [[1kig]] - bFX heavy chain catalytic domain + light chain EGF-like domain + anticoagulant peptide<br /> | ||
[[1fxy]] – hFX/trypsin + PPR-CMK | [[1fxy]] – hFX/trypsin + PPR-CMK | ||
==Additional Resources== | ==Additional Resources== | ||
