Prp8: Difference between revisions
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=Structure of Prp8= | =Structure of Prp8= | ||
{{ | {{STRUCTURE_3sbg| PDB=3sbg | SIZE=400| SCENE= |right|CAPTION='Prp8 C-terminus residues 1836 - 2397 [[3sbg]] }} | ||
Prp8's structure can be summarized as an amalgamation of domains from a variety of proteins, each of which has been slightly modified from their conventional forms and are now unique to Prp8. The major features present in Prp8 are a proline rich region, nuclear localization signal, bromodomain, reverse transcriptase-like domain, RNase H-like domain, and finally a metalloprotease/Jab1-like domain <ref name='Prp8, the pivotal protein of the spliceosomal catalytic center evolved from a retroelement-encoded reverse transcriptase'>DOI:10.1261/rna.2396011</ref>. | Prp8's structure can be summarized as an amalgamation of domains from a variety of proteins, each of which has been slightly modified from their conventional forms and are now unique to Prp8. The major features present in Prp8 are a proline rich region, nuclear localization signal, bromodomain, reverse transcriptase-like domain, RNase H-like domain, and finally a metalloprotease/Jab1-like domain <ref name='Prp8, the pivotal protein of the spliceosomal catalytic center evolved from a retroelement-encoded reverse transcriptase'>DOI:10.1261/rna.2396011</ref>. | ||
