1i1j: Difference between revisions

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[[Image:1i1j.gif|left|200px]]<br />

[[Image:1i1j.gif|left|200px]]<br /><applet load="1i1j" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1i1j" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1i1j, resolution 1.39Å" />

'''STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS'''<br />

==Overview==

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted, from both chondrocytes and malignant melanoma cells. MIA has been reported, to have effects on cell growth and adhesion, and it may play a role in, melanoma metastasis and cartilage development. We report the 1.4-A crystal, structure of human MIA, which consists of an Src homology 3 (SH3)-like, domain with N- and C-terminal extensions of about 20 aa. each. The N- and, C-terminal extensions add additional structural elements to the SH3, domain, forming a previously undescribed fold. MIA is a representative of, a recently identified family of proteins and is the first structure of a, secreted protein with an SH3 subdomain. The structure also suggests a, likely protein interaction site and suggests that, unlike conventional SH3, domains, MIA does not recognize polyproline helices.

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.

==Disease==

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==About this Structure==

1I1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA].

1I1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Alber, T.]]

[[Category: Bazan, J.F.]]

[[Category: Bazan, J F.]]

[[Category: Handel, T.M.]]

[[Category: Handel, T M.]]

[[Category: Holton, J.M.]]

[[Category: Holton, J M.]]

[[Category: Lougheed, J.C.]]

[[Category: Lougheed, J C.]]

[[Category: sh3 subdomain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:25:~~14 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:00 2008''

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-[[Image:1i1j.gif|left|200px]]<br />
+[[Image:1i1j.gif|left|200px]]<br /><applet load="1i1j" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1i1j" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1i1j, resolution 1.39&Aring;" />
 '''STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS'''<br />
 ==Overview==
-Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted, from both chondrocytes and malignant melanoma cells. MIA has been reported, to have effects on cell growth and adhesion, and it may play a role in, melanoma metastasis and cartilage development. We report the 1.4-A crystal, structure of human MIA, which consists of an Src homology 3 (SH3)-like, domain with N- and C-terminal extensions of about 20 aa. each. The N- and, C-terminal extensions add additional structural elements to the SH3, domain, forming a previously undescribed fold. MIA is a representative of, a recently identified family of proteins and is the first structure of a, secreted protein with an SH3 subdomain. The structure also suggests a, likely protein interaction site and suggests that, unlike conventional SH3, domains, MIA does not recognize polyproline helices.
+Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-I1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA].
+I1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Alber, T.]]
-[[Category: Bazan, J.F.]]
+[[Category: Bazan, J F.]]
-[[Category: Handel, T.M.]]
+[[Category: Handel, T M.]]
-[[Category: Holton, J.M.]]
+[[Category: Holton, J M.]]
-[[Category: Lougheed, J.C.]]
+[[Category: Lougheed, J C.]]
 [[Category: sh3 subdomain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:25:14 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:00 2008''