Mediator: Difference between revisions

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The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of mediator from ''S.cerevisiae'' is made of seven subunits which are Med22(Srb6), Med20(Srb2), Med18(Srb5), Med17(Srb4), Med11, Med6, and Med8.<ref name="nature" /> Of these subunits, Med11, Med17(Srb4), and Med22(Srb6) make the mini-head of the head module. The subunits of the core-head plus the subunits of the mini-head are what make up full head structure. The structure shows the three domains: the neck, which is shown by pink helices, the fixed jaw, which is shown by mostly pink helices and a few yellow beta sheets, and the movable jaw, which is shown by mostly yellow beta sheets and a few pink helices.
The <scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene> of mediator from ''S.cerevisiae'' is made of seven subunits which are Med22(Srb6), Med20(Srb2), Med18(Srb5), Med17(Srb4), Med11, Med6, and Med8.<ref name="nature" /> Of these subunits, Med11, Med17(Srb4), and Med22(Srb6) make the mini-head of the head module. The subunits of the core-head plus the subunits of the mini-head are what make up full head structure. The structure shows the three domains: the neck, which is shown by pink helices, the fixed jaw, which is shown by mostly pink helices and a few yellow beta sheets, and the movable jaw, which is shown by mostly yellow beta sheets and a few pink helices.


==3D structures of mediator==


[[3rj1]] – Med6 + Med8 + Med11 + Med17 + Med18 + Med20 + Med22 - yeast<br />
[[1yke]], [[1ykh]] – Med7 + Med21 <br />
[[3fbi]], [[3fbn]] – Med7 N terminal + Med31<br />
[[3c0t]] - Med8 C terminal + Med18<br />
[[2hzs]] – Med8 C terminal + Med18 + Med20<br />
[[3r84]] - Med11 + Med22 (mutant)<br />
[[2lpb]] - Med15 + general control protein GCN4<br />
[[2hzm – Med18 + Med20<br />
[[2l23]], [[2l6u]], [[2ky6]], [[2xnf]] – Med25 activator-interacting domain - NMR