3qi2: Difference between revisions

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[[Image:3qi2.png|left|200px]]
[[Image:3qi2.png|left|200px]]


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{{STRUCTURE_3qi2|  PDB=3qi2  |  SCENE=  }}  
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===A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco===
===A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco===


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Revision as of 10:24, 8 August 2012

File:3qi2.png

Template:STRUCTURE 3qi2

A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco

Template:ABSTRACT PUBMED 22383884

About this Structure

3qi2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis. PLoS Pathog. 2012 Feb;8(2):e1002553. Epub 2012 Feb 23. PMID:22383884 doi:10.1371/journal.ppat.1002553
  2. Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B. Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. J Mol Biol. 2007 Aug 31;371(5):1392-404. Epub 2007 Jun 8. PMID:17603074 doi:10.1016/j.jmb.2007.05.096
  3. Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 2002 Apr 25;416(6883):878-81. PMID:11976690 doi:https://dx.doi.org/10.1038/416878a

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