Motilin: Difference between revisions

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Motilin is a gastrointestinal peptide hormone released by the M-Cells in the epithelium of the small intestine. Its primary function is to increase gastric motility, that is, movement of digestive matter through the gut. It does so by stimulating contractions of the smooth muscle surrounding the intestines. In fasting humans, motilin is responsible for initiating the migrating motor complex, a coordinated peristalsis that clears material from the intestine, depositing it in the colon. Motilin secretion seems to be triggered by a high pH in the duodenum in most mammals. <ref>Norris, David O. ''Vertebrate Endocrinology'' (4th ed.). Elsevier Inc. 2007. p 441.</ref> Motilin has also been shown to stimulate the emptying of the gallbladder into the small intestine. <ref>Luiking, Y. C. et al. "Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder." Neurogastroenterology & Motility, Volume 15, Issue 2, pp 103–111, April 2003</ref>

'''Motilin''' is a gastrointestinal peptide hormone released by the M-Cells in the epithelium of the small intestine. Its primary function is to increase gastric motility, that is, movement of digestive matter through the gut. It does so by stimulating contractions of the smooth muscle surrounding the intestines. In fasting humans, motilin is responsible for initiating the migrating motor complex, a coordinated peristalsis that clears material from the intestine, depositing it in the colon. Motilin secretion seems to be triggered by a high pH in the duodenum in most mammals. <ref>Norris, David O. ''Vertebrate Endocrinology'' (4th ed.). Elsevier Inc. 2007. p 441.</ref> Motilin has also been shown to stimulate the emptying of the gallbladder into the small intestine. <ref>Luiking, Y. C. et al. "Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder." Neurogastroenterology & Motility, Volume 15, Issue 2, pp 103–111, April 2003</ref>

==Pharmacology==

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	Motilin is a gastrointestinal peptide hormone released by the M-Cells in the epithelium of the small intestine. Its primary function is to increase gastric motility, that is, movement of digestive matter through the gut. It does so by stimulating contractions of the smooth muscle surrounding the intestines. In fasting humans, motilin is responsible for initiating the migrating motor complex, a coordinated peristalsis that clears material from the intestine, depositing it in the colon. Motilin secretion seems to be triggered by a high pH in the duodenum in most mammals. <ref>Norris, David O. ''Vertebrate Endocrinology'' (4th ed.). Elsevier Inc. 2007. p 441.</ref> Motilin has also been shown to stimulate the emptying of the gallbladder into the small intestine. <ref>Luiking, Y. C. et al. "Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder." Neurogastroenterology & Motility, Volume 15, Issue 2, pp 103–111, April 2003</ref>		'''Motilin''' is a gastrointestinal peptide hormone released by the M-Cells in the epithelium of the small intestine. Its primary function is to increase gastric motility, that is, movement of digestive matter through the gut. It does so by stimulating contractions of the smooth muscle surrounding the intestines. In fasting humans, motilin is responsible for initiating the migrating motor complex, a coordinated peristalsis that clears material from the intestine, depositing it in the colon. Motilin secretion seems to be triggered by a high pH in the duodenum in most mammals. <ref>Norris, David O. ''Vertebrate Endocrinology'' (4th ed.). Elsevier Inc. 2007. p 441.</ref> Motilin has also been shown to stimulate the emptying of the gallbladder into the small intestine. <ref>Luiking, Y. C. et al. "Differential effects of motilin on interdigestive motility of the human gastric antrum, pylorus, small intestine and gallbladder." Neurogastroenterology & Motility, Volume 15, Issue 2, pp 103–111, April 2003</ref>

	==Pharmacology==		==Pharmacology==