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==Overview==

Importin alpha is the nuclear import receptor that recognizes classical, monopartite and bipartite nuclear localization signals (NLSs). The, structure of mouse importin alpha has been determined at 2.5 A resolution., The structure shows a large C-terminal domain containing armadillo, repeats, and a less structured N-terminal importin beta-binding domain, containing an internal NLS bound to the NLS-binding site. The structure, explains the regulatory switch between the cytoplasmic, high-affinity, form, and the nuclear, low-affinity form for NLS binding of the nuclear, import receptor predicted by the current models of nuclear import., Importin beta conceivably converts the low- to high-affinity form by, binding to a site overlapping the autoinhibitory sequence. The structure, also has implications for understanding NLS recognition, and the, structures of armadillo and HEAT repeats.

Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-terminal domain containing armadillo repeats, and a less structured N-terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site. The structure explains the regulatory switch between the cytoplasmic, high-affinity form, and the nuclear, low-affinity form for NLS binding of the nuclear import receptor predicted by the current models of nuclear import. Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence. The structure also has implications for understanding NLS recognition, and the structures of armadillo and HEAT repeats.

==About this Structure==

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[[Category: nuclear localization signal]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Importin alpha is the nuclear import receptor that recognizes classical, monopartite and bipartite nuclear localization signals (NLSs). The, structure of mouse importin alpha has been determined at 2.5 A resolution., The structure shows a large C-terminal domain containing armadillo, repeats, and a less structured N-terminal importin beta-binding domain, containing an internal NLS bound to the NLS-binding site. The structure, explains the regulatory switch between the cytoplasmic, high-affinity, form, and the nuclear, low-affinity form for NLS binding of the nuclear, import receptor predicted by the current models of nuclear import., Importin beta conceivably converts the low- to high-affinity form by, binding to a site overlapping the autoinhibitory sequence. The structure, also has implications for understanding NLS recognition, and the, structures of armadillo and HEAT repeats.
+Importin alpha is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin alpha has been determined at 2.5 A resolution. The structure shows a large C-terminal domain containing armadillo repeats, and a less structured N-terminal importin beta-binding domain containing an internal NLS bound to the NLS-binding site. The structure explains the regulatory switch between the cytoplasmic, high-affinity form, and the nuclear, low-affinity form for NLS binding of the nuclear import receptor predicted by the current models of nuclear import. Importin beta conceivably converts the low- to high-affinity form by binding to a site overlapping the autoinhibitory sequence. The structure also has implications for understanding NLS recognition, and the structures of armadillo and HEAT repeats.
 ==About this Structure==
@@ Line 20: / Line 20: @@
 [[Category: nuclear localization signal]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:50:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:45 2008''