1ico: Difference between revisions

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[[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ico" />

'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''<br />

==Overview==

Here we report the creation of a predominantly beta-structured, mini-protein motif. The design target is based on the naturally occurring, toxin hand (TH) motifs that are composed of four disulfide bonds and three, loops that form a 'hand'. Analysis and subsequent modification of several, generations of mini-proteins produced the final 29-residue mini-protein., The structured motif of this new mini-protein provides insight into the, compensatory changes that result in the formation of a tightly packed, hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein, design and a valuable, yet compact, model system for the study of, beta-sheet structure in water.

Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.

==About this Structure==

1ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].

1ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].

==Reference==

Line 13:

[[Category: Protein complex]]

[[Category: Imperiali, B.]]

[[Category: Ottesen, J.J.]]

[[Category: Ottesen, J J.]]

[[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sat Nov 24~~ 21:47:~~31 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:30 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ico.jpg|left|200px]]<br /><applet load="1ico" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ico" />
 '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX'''<br />
 ==Overview==
-Here we report the creation of a predominantly beta-structured, mini-protein motif. The design target is based on the naturally occurring, toxin hand (TH) motifs that are composed of four disulfide bonds and three, loops that form a 'hand'. Analysis and subsequent modification of several, generations of mini-proteins produced the final 29-residue mini-protein., The structured motif of this new mini-protein provides insight into the, compensatory changes that result in the formation of a tightly packed, hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein, design and a valuable, yet compact, model system for the study of, beta-sheet structure in water.
+Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
 ==About this Structure==
-ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
+ICO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Protein complex]]
 [[Category: Imperiali, B.]]
-[[Category: Ottesen, J.J.]]
+[[Category: Ottesen, J J.]]
 [[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 21:47:31 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:30 2008''