1ij9: Difference between revisions

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==Overview==

An X-ray crystal structure of two N-terminal integrin-binding IgSF domains, of human VCAM-1 is reported. This new crystal form shows an unusual and, highly hydrated packing arrangement in which over 80% of the crystal is, occupied by solvent. The relative orientations of the two domains adopt a, new intermediate conformation. The tilt angle between the two domains is, 19.4 degrees, compared with other related structures that have tilt angles, ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows, that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in, defining the interdomain conformations.

An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.

==Disease==

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[[Category: Bilsland, M.]]

[[Category: Taylor, P.]]

[[Category: Walkinshaw, M.D.]]

[[Category: Walkinshaw, M D.]]

[[Category: integrin solvation]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:31 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-An X-ray crystal structure of two N-terminal integrin-binding IgSF domains, of human VCAM-1 is reported. This new crystal form shows an unusual and, highly hydrated packing arrangement in which over 80% of the crystal is, occupied by solvent. The relative orientations of the two domains adopt a, new intermediate conformation. The tilt angle between the two domains is, 19.4 degrees, compared with other related structures that have tilt angles, ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows, that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in, defining the interdomain conformations.
+An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
 ==Disease==
@@ Line 18: / Line 18: @@
 [[Category: Bilsland, M.]]
 [[Category: Taylor, P.]]
-[[Category: Walkinshaw, M.D.]]
+[[Category: Walkinshaw, M D.]]
 [[Category: integrin solvation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:01:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:31 2008''