G15SecL05Tpc3: Difference between revisions
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== Outer Surface Protein B (Osp-B) of the ''Borrelia burgdorferi'' Spirochete Bacterium (Title) == | == Outer Surface Protein B (Osp-B) of the ''Borrelia burgdorferi'' Spirochete Bacterium (Title) == | ||
<Structure load='1rjl' size=' | <Structure load='1rjl' size='300' frame='true' align='right' caption='Fab H6831, Light and Heavy Chains' scene='Insert optional scene name here' /> | ||
<Structure load='1rjl' size='300' frame='true' align='right' caption='Osp-B Structure, Bound' scene='Insert optional scene name here' /> | |||
<scene name='G15SecL05Tpc3/Ospb/1'>Osp-B</scene> is a primary outer-surface lipoprotein molecule found in the Lyme disease spirochete ''Borrelia burgdorferi'', a molecule essential for the survival of the bacterium. Since its primary function is to serve both as a site of antibody recognition and as the microvillar attachment to the ''Ixodes scapularis'' midgut, it is constitutively expressed. | <scene name='G15SecL05Tpc3/Ospb/1'>Osp-B</scene> is a primary outer-surface lipoprotein molecule found in the Lyme disease spirochete ''Borrelia burgdorferi'', a molecule essential for the survival of the bacterium. Since its primary function is to serve both as a site of antibody recognition and as the microvillar attachment to the ''Ixodes scapularis'' midgut, it is constitutively expressed. | ||
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*1. Becker, M., Bunikis, J., Lade, B.D, Dunn, J.J., Barbour, A.G., Lawson, C.L. “Structural Investigation of Borrelia burgdorferi OspB, a BactericidalFab Target” The Journal of Biological Chemistry; Vol. 280, No.17, issue of April 29, pp. 17363- 17370, 2005 | *1. Becker, M., Bunikis, J., Lade, B.D, Dunn, J.J., Barbour, A.G., Lawson, C.L. “Structural Investigation of Borrelia burgdorferi OspB, a BactericidalFab Target” The Journal of Biological Chemistry; Vol. 280, No.17, issue of April 29, pp. 17363- 17370, 2005 | ||
*2. Connolly, S.E., Benach, J.L. “The Versatile Roles of Antibodies in Borrelia Infections” Nature Reviews: Microbiology, Volume 3, May 2005, pp. 411-420 | *2. Connolly, S.E., Benach, J.L. “The Versatile Roles of Antibodies in Borrelia Infections” Nature Reviews: Microbiology, Volume 3, May 2005, pp. 411-420 | ||
*3. LaRocca, T.J., Benach, J.L. 2008 “The Important and Diverse Roles of Antibodies in the Host Response to Borrelia Infections” Specialization and Complementation of Humoral Immune Responses to in Infection. Current Topics in Microbiology and Immunology 319 | |||
