G14secL04Tpc3: Difference between revisions

Line 12:

form two sheets that bend, along with the final <scene name='G14secL04Tpc3/8-12_beta_strands_showing/2'>alpha-helix</scene>

, into the <scene name='G14secL04Tpc3/C-terminal_barrel_domain/4'>C-terminal barrel domain </scene>

(17368). It has been shown that OspB deficient spirochetes lack the ability to bind to the tick gut. Further studies suggest that the structural barrel domain is what gives OspB the ability to adhere to the tick gut wall. The barrel domain cavity could serve as the binding site for an exposed protein loop, small peptide, or linear saccharide hanging off the tick gut wall. <scene name='G14secL04Tpc3/1-4_beta_strands_showing/1'>Beta strands 1-4 </scene> on the free OspB are cleaved when OspB is bound to antibody fragment H6831, suggesting that it’s removed by the proteolysis in the H6831-bound complex. This suggests that H6831 is good candidate for vaccine.

(17368). <ref> It has been shown that OspB deficient spirochetes lack the ability to bind to the tick gut </ref>. <ref> Further studies suggest that the structural barrel domain is what gives OspB the ability to adhere to the tick gut wall </ref>. The barrel domain cavity could serve as the binding site for an exposed protein loop, small peptide, or linear saccharide hanging off the tick gut wall. <scene name='G14secL04Tpc3/1-4_beta_strands_showing/1'>Beta strands 1-4 </scene> on the free OspB are cleaved when OspB is bound to antibody fragment H6831, suggesting that it’s removed by the proteolysis in the H6831-bound complex. This suggests that H6831 is good candidate for vaccine.

==OspB complexed with H6831 Antibody Fab Fragment==

G14secL04Tpc3: Difference between revisions

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@@ Line 12: / Line 12: @@
 form two sheets that bend, along with the final <scene name='G14secL04Tpc3/8-12_beta_strands_showing/2'>alpha-helix</scene>
 , into the <scene name='G14secL04Tpc3/C-terminal_barrel_domain/4'>C-terminal barrel domain </scene>
-(17368).  It has been shown that OspB deficient spirochetes lack the ability to bind to the tick gut. Further studies suggest that the structural barrel domain is what gives OspB the ability to adhere to the tick gut wall. The barrel domain cavity could serve as the binding site for an exposed protein loop, small peptide, or linear saccharide hanging off the tick gut wall. <scene name='G14secL04Tpc3/1-4_beta_strands_showing/1'>Beta strands 1-4 </scene> on the free OspB are cleaved when OspB is bound to antibody fragment H6831, suggesting that it’s removed by the proteolysis in the H6831-bound complex. This suggests that H6831 is good candidate for vaccine.
+(17368). <ref> It has been shown that OspB deficient spirochetes lack the ability to bind to the tick gut </ref>. <ref> Further studies suggest that the structural barrel domain is what gives OspB the ability to adhere to the tick gut wall </ref>. The barrel domain cavity could serve as the binding site for an exposed protein loop, small peptide, or linear saccharide hanging off the tick gut wall. <scene name='G14secL04Tpc3/1-4_beta_strands_showing/1'>Beta strands 1-4 </scene> on the free OspB are cleaved when OspB is bound to antibody fragment H6831, suggesting that it’s removed by the proteolysis in the H6831-bound complex. This suggests that H6831 is good candidate for vaccine.
 ==OspB complexed with H6831 Antibody Fab Fragment==