G18secL03Tpc4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Olivia Cary (talk | contribs) |
Olivia Cary (talk | contribs) |
||
| Line 22: | Line 22: | ||
Researchers believe that an OspC based vaccine would be more effective against Lyme disease than the current OspA based vaccine once further research is conducted regarding the three dimensional structure of OspC's, especially the structure of invasive strains <ref>D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [http://dx.doi.org/DOI:10.1093/emboj/20.5.971]</ref>. | Researchers believe that an OspC based vaccine would be more effective against Lyme disease than the current OspA based vaccine once further research is conducted regarding the three dimensional structure of OspC's, especially the structure of invasive strains <ref>D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [http://dx.doi.org/DOI:10.1093/emboj/20.5.971]</ref>. | ||
==== Main Advantages of Developing OspC-based Vaccine ==== | ==== Main Advantages of Developing OspC-based Vaccine ==== | ||
Unlike OspC, the OspA protein is only present in the Borrelia burgdorferi while they are in the midgut of the cold blooded tick, and not in the host <ref>D. Greenburg, M.S. Rowe. Brookhaven Scientists Determine Key Lime Disease Protein Structure.Brookhaven National Laboratory (2001)[http://www.bnl.gov/bnlweb/pubaf/pr/2001/bnlpr022801.htm]</ref> | |||
==== Main Problems with Application of OspC-based Vaccine ==== | ==== Main Problems with Application of OspC-based Vaccine ==== | ||
'''Notes and References'''<references/> | '''Notes and References'''<references/> | ||
