G04SecL04Tpc1: Difference between revisions
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<Structure load='1RJL' size='500' frame='true' align='right' caption='OspB and Fab complex' scene='G04SecL04Tpc1/1rjl/1' /> | <Structure load='1RJL' size='500' frame='true' align='right' caption='OspB and Fab complex' scene='G04SecL04Tpc1/1rjl/1' /> | ||
==Structure== | |||
===Osp-B H6831 complex=== | |||
The complex formed by the C-terminal end of Outer Surface Protein B and H6831 displays a <scene name='G04SecL04Tpc1/Osp_b_fab_complex/1'>truncated form of Osp-B</scene>, purple,Binding with the Fab region of the H6831, light blue. | The complex formed by the C-terminal end of Outer Surface Protein B and H6831 displays a <scene name='G04SecL04Tpc1/Osp_b_fab_complex/1'>truncated form of Osp-B</scene>, purple,Binding with the Fab region of the H6831, light blue. | ||
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=== Comparison between OspB-H6831 and OspA-LA2=== | === Comparison between OspB-H6831 and OspA-LA2=== | ||
<Structure load='1FJ1' size='500' frame='true' align='right' caption='OspA and LA2 bound complex' scene='G04SecL04Tpc1/Ospa/1' /> | |||
Another surface protein of note in the B. Burgdorferi is <scene name='G04SecL04Tpc1/Ospa_complex/1'>OspA</scene>, which is 53% similar to OspB. This is due to some structural similarities in the proteins. Also, the change in conformation of OspA after binding to the LA2 antibody is very similar to that of OspB when binding with H6831. The H6831 and LA2 antibodies are also structurally similar and both are bind at C-terminal of the particular surface protein (Becker et al. 2005). | Another surface protein of note in the B. Burgdorferi is <scene name='G04SecL04Tpc1/Ospa_complex/1'>OspA</scene>, which is 53% similar to OspB. This is due to some structural similarities in the proteins. Also, the change in conformation of OspA after binding to the LA2 antibody is very similar to that of OspB when binding with H6831. The H6831 and LA2 antibodies are also structurally similar and both are bind at C-terminal of the particular surface protein (Becker et al. 2005). | ||
