G13secL03Tpc3: Difference between revisions

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===Interactions===

The structure of Osp B shows that there are three exposed loops in which are affected by the antibody, H6831. The majority of interaction comes between the antibody’s heavy chain and <scene name='G13secL03Tpc3/Loop_2/1'>Loop 2</scene> on the lipoprotein, residues 250-254. The loop forms electrostatic interaction and hydrogen bond interactions with the antibody's heavy chain. Lysine 253, which resides on Loop 2 play an important role in the recognition of the antibody, thus the antibody having the most interaction with loop 2. The Lysine interacts with the antibody by forming hydrogen bonds with the glutamine and histidine on the heavy chain of H6831. <scene name='G13secL03Tpc3/Loop_1/1'>Loop 1</scene>, residues 231-233, also interacts with the Fab heavy chain forming two hydrogen bonds. Loop 3, residues 272-276, interact with the light chain, of the antibody with two hydrogen bonds. <ref name=Article2> PMID:15864264 </ref>

The structure of Osp B shows that there are three exposed loops in which are affected by the antibody, H6831. The majority of interaction comes between the antibody’s heavy chain and <scene name='G13secL03Tpc3/Loop_2/1'>Loop 2</scene> on the lipoprotein, residues 250-254. The loop forms electrostatic interaction and hydrogen bond interactions with the antibody's heavy chain. Lysine 253, which resides on Loop 2 play an important role in the recognition of the antibody, thus the antibody having the most interaction with loop 2. The Lysine interacts with the antibody by forming hydrogen bonds with the glutamine and histidine on the heavy chain of H6831. <scene name='G13secL03Tpc3/Loop_1/1'>Loop 1</scene>, residues 231-233, also interacts with the Fab heavy chain forming two hydrogen bonds. <scene name='G13secL03Tpc3/Loop_3/1'>Loop 3</scene>, residues 272-276, interact with the light chain, of the antibody with two hydrogen bonds. <ref name=Article2> PMID:15864264 </ref>

==Structural changes==

G13secL03Tpc3: Difference between revisions

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@@ Line 14: / Line 14: @@
 ===Interactions===
-The structure of Osp B shows that there are three exposed loops in which are affected by the antibody, H6831. The majority of interaction comes between the antibody’s heavy chain and <scene name='G13secL03Tpc3/Loop_2/1'>Loop 2</scene> on the lipoprotein, residues 250-254. The loop forms electrostatic interaction and hydrogen bond interactions with the antibody's heavy chain. Lysine 253, which resides on Loop 2 play an important role in the recognition of the antibody, thus the antibody having the most interaction with loop 2. The Lysine interacts with the antibody by forming hydrogen bonds with the glutamine and histidine on the heavy chain of H6831. <scene name='G13secL03Tpc3/Loop_1/1'>Loop 1</scene>, residues 231-233, also interacts with the Fab heavy chain forming two hydrogen bonds. Loop 3, residues 272-276, interact with the light chain, of the antibody with two hydrogen bonds. <ref name=Article2> PMID:15864264 </ref>
+The structure of Osp B shows that there are three exposed loops in which are affected by the antibody, H6831. The majority of interaction comes between the antibody’s heavy chain and <scene name='G13secL03Tpc3/Loop_2/1'>Loop 2</scene> on the lipoprotein, residues 250-254. The loop forms electrostatic interaction and hydrogen bond interactions with the antibody's heavy chain. Lysine 253, which resides on Loop 2 play an important role in the recognition of the antibody, thus the antibody having the most interaction with loop 2. The Lysine interacts with the antibody by forming hydrogen bonds with the glutamine and histidine on the heavy chain of H6831. <scene name='G13secL03Tpc3/Loop_1/1'>Loop 1</scene>, residues 231-233, also interacts with the Fab heavy chain forming two hydrogen bonds. <scene name='G13secL03Tpc3/Loop_3/1'>Loop 3</scene>, residues 272-276, interact with the light chain, of the antibody with two hydrogen bonds. <ref name=Article2> PMID:15864264 </ref>
 ==Structural changes==