G09SecL04Tpc2: Difference between revisions
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The c-terminal is heavily involved in the antigen:antibody complex unlike the n-terminal. The c-terminal houses a protruding ridge of three loops: loop 1 contains residues 203-220; loop 2 contains residues 224-233; loop 3 contains residues 246-257. These loops define the LA-2 (antibody) epitope. More specifically, the loops indicate where the antibody binds to the antigen. This protruding ridge coupled with OspA’s elongated fold gives the surface protein a high degree of mobility and surface exposure. | The c-terminal is heavily involved in the antigen:antibody complex unlike the n-terminal. The c-terminal houses a protruding ridge of three loops: loop 1 contains residues 203-220; loop 2 contains residues 224-233; loop 3 contains residues 246-257. These loops define the LA-2 (antibody) epitope. More specifically, the loops indicate where the antibody binds to the antigen. This protruding ridge coupled with OspA’s elongated fold gives the surface protein a high degree of mobility and surface exposure. | ||
=== LA-2 Recognition | === LA-2 Recognition === | ||
=== The Elusiveness of OspA === | === The Elusiveness of OspA === | ||
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==Additional Resources== | ==Additional Resources== | ||
[http://www.wadsworth.org/databank/borreli.htm Wadsworth Center: NYS Department of Health] | *[http://www.wadsworth.org/databank/borreli.htm Wadsworth Center: NYS Department of Health] | ||
*[http://www.cdc.gov/lyme/ CDC: Lyme Disease] | |||
[http://www.cdc.gov/lyme/ CDC: Lyme Disease] | |||
==References== | ==References== | ||
<references /> | <references /> | ||
