G13secL03Tpc3: Difference between revisions

The structure of Osp B shows that there are three exposed loops that are affected by the antibody, H6831. The majority of interaction occurs between the antibody’s heavy chain and <scene name='G13secL03Tpc3/Loop_2_final/1'>Loop 2</scene> on the lipoprotein, residues 250-254. The loop forms electrostatic interaction and hydrogen bond interactions with the antibody's heavy chain. Lysine 253, which resides on Loop 2, plays an important role in the recognition of the antibody, thus the antibody having the most interaction with loop 2. The Lysine interacts with the antibody by forming hydrogen bonds with the glutamine and histidine on the heavy chain of H6831. <scene name='G13secL03Tpc3/Loop_1/1'>Loop 1</scene>, residues 231-233, also interacts with the Fab heavy chain by forming two hydrogen bonds. <scene name='G13secL03Tpc3/Loop_3_final/2'>Loop 3</scene>, residues 272-276, interacts with the Fab light chain of the antibody with two hydrogen bonds. <ref name=Article2> PMID:15864264 </ref> Loop 3 contains Threonine 276, an amino acid that, along with Lysine 253, contributes most to the contact and binding of H6831 to OspB.