StudioG24SecL04Tpc5: Difference between revisions
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==Function in Immune System Evasion== | ==Function in Immune System Evasion== | ||
The contributions that VlsE brings to immune evasion of Lyme Disease in B. Burgderfori is based on the variability of said protein. The variable domain keeps the immune system guessing by constantly changing the their side chains. The variable region also protects the invariable region where antibodies generally target in order to help in phagocytosis. There in fact only three antibody chains that can bind to the most consistently active invariable region IR6. Even though the invariable regions take up most of the gene casette the variable region takes up a lot of the surface area. This variability is the reason why VlsE is located on membrane of the bacterium of Lyme disease. | The contributions that VlsE brings to immune evasion of Lyme Disease in ''B. Burgderfori'' is based on the variability of said protein. The variable domain keeps the immune system guessing by constantly changing the their side chains. The variable region also protects the invariable region where antibodies generally target in order to help in phagocytosis. There in fact only three antibody chains that can bind to the most consistently active invariable region IR6. Even though the invariable regions take up most of the gene casette the variable region takes up a lot of the surface area. This variability is the reason why VlsE is located on membrane of the bacterium of Lyme disease. | ||
==Clinical Application== | ==Clinical Application== | ||
