StudioG24SecL04Tpc5: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Tasfik Ahmed (talk | contribs) No edit summary |
||
| Line 42: | Line 42: | ||
==Function in Immune System Evasion== | ==Function in Immune System Evasion== | ||
The contributions that VlsE brings to immune evasion of Lyme Disease in B. Burgderfori is brought on by the property of antigenic variation. The variable domain of VlsE keeps the immune system guessing by constantly changing its side chains. The predicted amount of variations due to VlsE sequence is around 10^30 combinations providing ample evasion against immune responses. The variable region also protects the invariable region by covering the latter region, providing antibodies with a small area to attach to the antigen. There are only 4 amino residues on IR6 that are exposed on the surface of the protein and allowed for binding by antibody. They are Lysine-276, Glutamine-279, Lysine-291, and Lysine-294. The IR6 region exposed is only 13.7% of the entire surface area of VlsE, making immune evasion even easier.<ref name="A">PMID:10569796</ref> | The contributions that VlsE brings to immune evasion of Lyme Disease in B. Burgderfori is brought on by the property of antigenic variation. The variable domain of VlsE keeps the immune system guessing by constantly changing its side chains. The predicted amount of variations due to VlsE sequence is around 10^30 combinations providing ample evasion against immune responses. The variable region also protects the invariable region by covering the latter region, providing antibodies with a small area to attach to the antigen. There are only 4 amino residues on IR6 that are exposed on the surface of the protein and allowed for binding by antibody. They are Lysine-276, Glutamine-279, Lysine-291, and Lysine-294. The IR6 region exposed is only 13.7% of the entire surface area of VlsE, making immune evasion even easier.<ref name="A">PMID:10569796</ref> | ||
<scene name='StudioG24SecL04Tpc5/The_resudie/2'>Exposed Residues of IR6 highlighted in blue</scene> | |||
==Clinical Application== | ==Clinical Application== | ||
