G09SecL04Tpc2: Difference between revisions
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====Hiding in less accessible compartments such as the Extracellular Matrix==== | ====Hiding in less accessible compartments such as the Extracellular Matrix==== | ||
Spirochetes from Borrelia survive by hiding in less accessible regions such as the extracellular matrix. From here they are able to invade multiple organ sites and avoid being easily found. Leukocytes in the bloodstream are not able to detect the spirochetes in the extracellular matrix. Borrelia is able to bind to many proteins in the extracellular matrix ensuring the survival of its spirochetes. This is supported by the finding that spirochete associated plasmin degrades the protein fibronectin which is located on the extracellular matrix. | Spirochetes from Borrelia survive by hiding in less accessible regions such as the extracellular matrix. From here they are able to invade multiple organ sites and avoid being easily found. Leukocytes in the bloodstream are not able to detect the spirochetes in the extracellular matrix. Borrelia is able to bind to many proteins in the extracellular matrix ensuring the survival of its spirochetes. This is supported by the finding that spirochete associated plasmin degrades the protein fibronectin which is located on the extracellular matrix.<ref name=art7>PMID:7809084</ref> | ||
===Crossing the Blood-Brain Barrier to the CNS=== | ===Crossing the Blood-Brain Barrier to the CNS=== | ||
