G09SecL04Tpc2: Difference between revisions
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'''Outer Surface Protein A (OspA)''' is a major [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete] which is a causative agent of Lyme Disease. The three loops in the C-terminus define the antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA | '''Outer Surface Protein A (OspA)''' is a major [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete] which is a causative agent of Lyme Disease. The three loops in the C-terminus define the [http://en.wikipedia.org/wiki/Protein_dimer dimerized] antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA dimer with LA-2 Antibody complex</scene>. The interaction between the loops and the LA-2 (antibody) forms the basis for OspA vaccination. Along with other surface proteins, OspA has many important functions that are associated with [http://en.wikipedia.org/wiki/Lyme_Disease Lyme Disease] such as late stage neurological disorders including acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis Neuroborreliosis]. | ||