G09SecL04Tpc2: Difference between revisions
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'''Outer Surface Protein A (OspA)''' is a major [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete], which is a causative agent of [http://en.wikipedia.org/wiki/Lyme_Disease Lyme Disease]. The three loops in the C-terminus define the [http://en.wikipedia.org/wiki/Protein_dimer dimerized] antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA dimer with LA-2 Antibody complex</scene>. The interaction between the loops and the LA-2 antibody forms the basis for successful OspA vaccination of this infectious disease. Most early symptoms include fever and headaches that are often eliminated through antibiotics. On the other hand, OspA has many important functions that are associated with late stage neurological disorders of the central nervous system including acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis Neuroborreliosis], which can be extremely difficult to treat and disabling of the physical body itself. | '''Outer Surface Protein A (OspA)''' is a major [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the ''borrelia burgdorferi'' [http://en.wikipedia.org/wiki/Spirochete spirochete], which is a causative agent of [http://en.wikipedia.org/wiki/Lyme_Disease Lyme Disease]. The three loops in the C-terminus define the [http://en.wikipedia.org/wiki/Protein_dimer dimerized] antigen-antibody complex. Shown to the right is the <scene name='G09SecL04Tpc2/Osp_a_dimer_with_la-2_antibody/1'> OspA dimer with LA-2 Antibody complex</scene>. The interaction between the loops and the LA-2 antibody forms the basis for successful OspA vaccination of this infectious disease. Most early symptoms include fever and headaches that are often eliminated through antibiotics. On the other hand, OspA has many important functions that are associated with late stage neurological disorders of the central nervous system including acute Lyme [http://en.wikipedia.org/wiki/Neuroborreliosis Neuroborreliosis], which can be extremely difficult to treat and disabling of the physical body itself. <Structure load='1FJ1' size='400' align='right' caption='OspA Dimer with LA-2 Antibody DImer'/> | ||
