G09SecL04Tpc2: Difference between revisions
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<Structure load='1fj1' size='300' frame='true' align='right' caption='OspA and LA-2 Fab Complex ' scene='G09SecL04Tpc2/Ospala2/1' /> | <Structure load='1fj1' size='300' frame='true' align='right' caption='OspA and LA-2 Fab Complex ' scene='G09SecL04Tpc2/Ospala2/1' /> | ||
<scene name='G09SecL04Tpc2/Ospala2/1'>Reset Model</scene> | <scene name='G09SecL04Tpc2/Ospala2/1'>Reset Model</scene> | ||
Since [http://en.wikipedia.org/wiki/Nuclear_magnetic_resonance NMR] chemical shifts are greatly sensitive to magnetic (local) environments, they are great for sensing conformational changes; NMR chemical-shift perturbation was an important method in identifying this three- loop epitope of OspA, but more importantly it also portrayed that these three loops were strongly antigenic.<ref name=art3>PMID:11183781</ref> In a study conducted in 2000, Wei Ding and fellow colleagues illustrated the <scene name='G09SecL04Tpc2/Ospala2/2'>binding site</scene> through NMR and [http://en.wikipedia.org/wiki/Crystallography crystallography]: LA-2 makes a concave-like groove over the 3 loops on the tip of the c-terminus through direct contact by heavy and light chains includng interactions between its R groups.<ref name=art3>PMID:11183781</ref> | Since [http://en.wikipedia.org/wiki/Nuclear_magnetic_resonance NMR] chemical shifts are greatly sensitive to magnetic (local) environments, they are great for sensing conformational changes; NMR chemical-shift perturbation was an important method in identifying this three- loop epitope of OspA, but more importantly it also portrayed that these three loops were strongly antigenic.<ref name=art3>PMID:11183781</ref> In a study conducted in 2000, Wei Ding and fellow colleagues illustrated the <scene name='G09SecL04Tpc2/Ospala2/2'>binding site</scene> through NMR and [http://en.wikipedia.org/wiki/Crystallography crystallography]: LA-2 makes a concave-like groove over the 3 loops on the tip of the c-terminus through direct contact by heavy and light chains includng interactions between its R groups.<ref name=art3>PMID:11183781</ref> | ||
