1jm7: Difference between revisions
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New page: left|200px<br /> <applet load="1jm7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jm7" /> '''Solution structure of the BRCA1/BARD1 RING-... |
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[[Image:1jm7.gif|left|200px]]<br /> | [[Image:1jm7.gif|left|200px]]<br /><applet load="1jm7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1jm7" size=" | |||
caption="1jm7" /> | caption="1jm7" /> | ||
'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer'''<br /> | '''Solution structure of the BRCA1/BARD1 RING-domain heterodimer'''<br /> | ||
==Overview== | ==Overview== | ||
The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 | The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1JM7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JM7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JM7 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brzovic, P | [[Category: Brzovic, P S.]] | ||
[[Category: Hoyt, D | [[Category: Hoyt, D W.]] | ||
[[Category: King, M | [[Category: King, M C.]] | ||
[[Category: Klevit, R | [[Category: Klevit, R E.]] | ||
[[Category: Rajagopal, P.]] | [[Category: Rajagopal, P.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: zinc-binding protein]] | [[Category: zinc-binding protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:17 2008'' | ||
