Argonaute: Difference between revisions
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===Paz Domain=== | ===Paz Domain=== | ||
The <scene name='Argonaute/Ago2-paz/1'>Paz Domain</scene> is responsible for binding to the 3'-end overhangs of single-stranded RNAs and siRNA duplexes <ref name='ref3'>pmid 15152257</ref> and was shown to be essential for RISC activation <ref name=' | The <scene name='Argonaute/Ago2-paz/1'>Paz Domain</scene> is responsible for binding to the 3'-end overhangs of single-stranded RNAs and siRNA duplexes <ref name='ref3'>pmid 15152257</ref> and was shown to be essential for RISC activation <ref name='ref4'>pmid 22795694</ref>. <scene name='Argonaute/Ago2-paz-obfold/2'>The domain is composed of two subdomains:</scene> the first is similar to the OB fold, a well known nucleic acid binding fold; the second subdomain is composed of a beta-hairpin followed by an alpha-helix. The cleft in between these two subdomains appears to interact with the 3' ends of ssRNA <ref name='ref5'>pmid 14615801</ref> (<scene name='Argonaute/Ago2-paz-binding-cleft/2'>See in structure</scene>) | ||
===Piwi Domain=== | ===Piwi Domain=== | ||
