1jvl: Difference between revisions

[[Image:1jvl.gif|left|200px]]<br /><applet load="1jvl" size="350" color="white" frame="true" align="right" spinBox="true"  

The transfer of electrons between proteins is an essential step in biological energy production. Two protein redox partners are often artificially crosslinked to investigate the poorly understood mechanism by which they interact. To better understand the effect of crosslinking on electron transfer rates, we have constructed dimers of azurin by crosslinking the monomers. The measured electron exchange rates, combined with crystal structures of the dimers, demonstrate that the length of the linker can have a dramatic effect on the structure of the dimer and the electron transfer rate. The presence of ordered water molecules in the protein-protein interface may considerably influence the electronic coupling between redox centers.

1JVL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=CU:'>CU</scene>, <scene name='pdbligand=NI:'>NI</scene>, <scene name='pdbligand=144:'>144</scene> and <scene name='pdbligand=OPP:'>OPP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JVL OCA].  

[[Category: Amsterdam, I M.C van.]]

[[Category: Canters, G W.]]

[[Category: Rossi, G L.]]

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