Sandbox Reserved 508: Difference between revisions
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B. Quantitative representation of the changes in ROS levels corresponding to the fluorescence images in A using time-lapse confocal microscopy. The presence of UCP2 greatly reduces ROS levels, limiting damage to cardiac ventricular myocytes. | B. Quantitative representation of the changes in ROS levels corresponding to the fluorescence images in A using time-lapse confocal microscopy. The presence of UCP2 greatly reduces ROS levels, limiting damage to cardiac ventricular myocytes. | ||
== Figures == | == Figures == | ||
[[Image:BCSMART_11-12_Figure_1.JPG|left|375px|'''FIGURE 1: Movement of Protons (H+) Across Inner Mitochondrial Membrane'''<br> | [[Image:BCSMART_11-12_Figure_1.JPG|left|375px|thumb]] | ||
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'''FIGURE 1: Movement of Protons (H+) Across Inner Mitochondrial Membrane''' | |||
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1. The electron transport chain pumps protons (H+) into the inter membrane space. | 1. The electron transport chain pumps protons (H+) into the inter membrane space. | ||
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of ADP to ATP. | of ADP to ATP. | ||
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[[Image:BCSMART_11-12_Figure_2.JPG| | <br> | ||
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[[Image:BCSMART_11-12_Figure_2.JPG|left|375px|thumb]] | |||
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'''FIGURE 2: ROS Production''' | |||
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1. During reperfusion (return of blood flow), the electron transport chain sends more protons (H+) into the inter membrane space, producing a high concentration. | 1. During reperfusion (return of blood flow), the electron transport chain sends more protons (H+) into the inter membrane space, producing a high concentration. | ||
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-)]] | -)]] | ||
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[[Image:BCSMART_11-12_Figure_3.JPG|left|375px|thumb | [[Image:BCSMART_11-12_Figure_3.JPG|left|375px|thumb]] | ||
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'''FIGURE 3: UCP2 Relieving the High Concentration Gradient''' | |||
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One way the mitochondria can alleviate the proton buildup in the inter membrane space is to transport the protons (H+) back into the matrix. One possible protein involved in this transportation is uncoupling protein 2 (UCP2). | One way the mitochondria can alleviate the proton buildup in the inter membrane space is to transport the protons (H+) back into the matrix. One possible protein involved in this transportation is uncoupling protein 2 (UCP2). | ||
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1.UCP2 brings protons (H+) into the matrix, relieving the high concentration gradient. | 1.UCP2 brings protons (H+) into the matrix, relieving the high concentration gradient. | ||
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2.The “back up” of electrons and radical production is reduced, minimizing damage to cardiomyocytes. | 2.The “back up” of electrons and radical production is reduced, minimizing damage to cardiomyocytes. | ||
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[[Image:BCSMART_11-12_Figure_4.JPG| | [[Image:BCSMART_11-12_Figure_4.JPG|left|375px|thumb]] | ||
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'''FIGURE 4: Proposed Mechanisms for UCP2 Transport of Protons (H+)''' | |||
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There are two proposed mechanisms for UCP2 transport of protons (H+) into the mitochondria. | There are two proposed mechanisms for UCP2 transport of protons (H+) into the mitochondria. | ||
