Introduction to Evolutionary Conservation: Difference between revisions
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'''[[3c2i]]'''. Amino acid sequence in [[Amino acids#20_Standard_Amino_Acids_and_Mnemonics|1 letter code]]: | '''[[3c2i]]'''. Amino acid sequence in [[Amino acids#20_Standard_Amino_Acids_and_Mnemonics|1 letter code]]: | ||
<br><br> | <br><br> | ||
<span style="font-size: | <span style="font-size:150%; font-family:monospace;"><font color="gray"> ASASPKQRRS IIRD</font>RGPMYD | ||
DPTLPEGWTR KLKQRKSGRS AGKYDVYLIN | DPTLPEGWTR KLKQRKSGRS AGKYDVYLIN | ||
<br> | <br> | ||
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</span> | </span> | ||
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** R133C causes | ** Mutation R133C causes | ||
[http://workshops.molviz.org/slides/rett/rett.htm Rett syndrome], | [http://workshops.molviz.org/slides/rett/rett.htm Rett syndrome], | ||
a severe neurological disorder. | a severe neurological disorder. | ||
<br> | |||
E143 is highly variable, so mutations here are harmless and remain in the gene pool. | |||
<br> | <br> | ||
<font color="gray">Gray: disordered in crystal, absent in model 3c2i.</font> | <font color="gray">Gray: disordered in crystal, absent in model 3c2i.</font> | ||
