Introduction to Evolutionary Conservation: Difference between revisions
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<Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1' /> | <Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1' /> | ||
Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure, they form a conserved patch around the catalytic site. | Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure, they form a conserved patch around the catalytic site. | ||
Conserved surface patches identify functional regions of proteins. Less commonly, patches of high variability may also be functional. (Can you think of situations where high variability would be advantageous?<ref>Advantageous variability will be seen in these cases: [[5mhg]], [[2vaa]], [[3hi6]].</ref>) | |||
{{Clear}} | {{Clear}} | ||
