User:Eric Martz/Introduction to Structural Bioinformatics I: Difference between revisions
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:::*Folded domains fold spontaneously (Anfinson, 1960's<ref>For a brief overview of Anfinson's protein folding experiments in the 1960's, see the first paragraph at [[Intrinsically Disordered Protein]].</ref>), or with the help of [[chaperonins]]. | :::*Folded domains fold spontaneously (Anfinson, 1960's<ref>For a brief overview of Anfinson's protein folding experiments in the 1960's, see the first paragraph at [[Intrinsically Disordered Protein]].</ref>), or with the help of [[chaperonins]]. | ||
:::*The '''denaturation''' (unfolding) of a folded domain destroys its function. | :::*The '''denaturation''' (unfolding) of a folded domain destroys its function. | ||
:<span style="font-size:130%">3. Backbone Representation.</span> | |||
::A. [http://www.umass.edu/molvis/tutorials/hemoglobin/pepstruc.htm Peptides and Backbones] (within a tutorial on hemoglobin) | |||
::B. [http://firstglance.jmol.org/fg.htm?mol=1pgb Small Protein in FirstGlance] (use Vines, Cartoon) | |||
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::E. Crystallographers publish the [[asymmetric unit]] of the crystal. It may be identical with the [[biological unit]] (the functional form of the molecule), or it may be only part of the biological unit, or it may contain multiple copies of the biological unit. See [[Biological unit#Examples|examples]]. | ::E. Crystallographers publish the [[asymmetric unit]] of the crystal. It may be identical with the [[biological unit]] (the functional form of the molecule), or it may be only part of the biological unit, or it may contain multiple copies of the biological unit. See [[Biological unit#Examples|examples]]. | ||
:::Interchain contacts that occur in the asymmetric unit that are absent in the biological unit are an artifact of crystallization, termed [[crystal contacts]]. | :::Interchain contacts that occur in the asymmetric unit that are absent in the biological unit are an artifact of crystallization, termed [[crystal contacts]]. | ||
==III. Choose a Molecule to Explore== | ==III. Choose a Molecule to Explore== | ||
