2ca9: Difference between revisions
New page: left|200px<br /> <applet load="2ca9" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ca9, resolution 2.05Å" /> '''APO-NIKR FROM HELIC... |
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==About this Structure== | ==About this Structure== | ||
2CA9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]] with FMT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CA9 OCA]]. | 2CA9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]] with FMT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CA9 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transcriptional regulation]] | [[Category: transcriptional regulation]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:31:31 2007'' | ||
Revision as of 12:26, 30 October 2007
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APO-NIKR FROM HELICOBACTER PYLORI IN CLOSED TRANS-CONFORMATION
Overview
The survival of Helicobacter pylori in the human stomach critically relies, on the availability and use of nickel, an absolute cofactor of the, important virulence determinant urease. Nickel-responsive gene regulation, is mediated by HpNikR, a protein belonging to the ribbon-helix-helix, family of transcriptional regulators. Unlike its homologues, HpNikR acts, as both a repressor and an activator within an acid adaptation cascade. We, report the crystal structure of the full-length HpNikR in a nickel-free, conformation and two nickel-bound structures obtained in different, conditions: Ni1-HpNikR and Ni2-HpNikR. Apo-HpNikR shows the same global, fold as its bacterial homologues although with an unusual closed, trans-conformation and asymmetrical quaternary arrangement. The structure, of ... [(full description)]
About this Structure
2CA9 is a [Single protein] structure of sequence from [Helicobacter pylori] with FMT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis of the nickel response in Helicobacter pylori: crystal structures of HpNikR in Apo and nickel-bound states., Dian C, Schauer K, Kapp U, McSweeney SM, Labigne A, Terradot L, J Mol Biol. 2006 Aug 25;361(4):715-30. Epub 2006 Jul 7. PMID:16872629
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