1kik: Difference between revisions
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New page: left|200px<br /> <applet load="1kik" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kik" /> '''SH3 Domain of Lymphocyte Specific Kinase (L... |
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[[Image:1kik.gif|left|200px]]<br /> | [[Image:1kik.gif|left|200px]]<br /><applet load="1kik" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''SH3 Domain of Lymphocyte Specific Kinase (LCK)'''<br /> | '''SH3 Domain of Lymphocyte Specific Kinase (LCK)'''<br /> | ||
==Overview== | ==Overview== | ||
BACKGROUND: Protein tyrosine kinases are involved in signal transduction | BACKGROUND: Protein tyrosine kinases are involved in signal transduction pathways that regulate cell growth, differentiation, activation and transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein involved in T-cell- and IL2-receptor signaling. Three-dimensional structures are known for SH3, SH2 and kinase domains of Lck as well as for other tyrosine kinases. No structure is known for the unique domain of any Src-type tyrosine kinase. RESULTS: Lck(1-120) comprising unique and SH3 domains was structurally investigated by nuclear magnetic resonance spectroscopy. We found the unique domain, in contrast to the SH3 part, to have basically no defined structural elements. The solution structure of the SH3 part could be determined with very high precision. It does not show significant differences to Lck SH3 in the absence of the unique domain. Minor differences were observed to the X-ray structure of Lck SH3. CONCLUSION: The unique domain of Lck does not contain any defined structure elements in the absence of ligands and membranes. Presence of the unique domain is not relevant to the three-dimensional structure of the Lck SH3 domain. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1KIK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | 1KIK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KIK OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: tyrosine kinase]] | [[Category: tyrosine kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:34:31 2008'' | ||
