1kj3: Difference between revisions
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New page: left|200px<br /><applet load="1kj3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kj3, resolution 2.30Å" /> '''Mhc Class I H-2Kb mo... |
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[[Image:1kj3.jpg|left|200px]]<br /><applet load="1kj3" size=" | [[Image:1kj3.jpg|left|200px]]<br /><applet load="1kj3" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1kj3, resolution 2.30Å" /> | caption="1kj3, resolution 2.30Å" /> | ||
'''Mhc Class I H-2Kb molecule complexed with pKB1 peptide'''<br /> | '''Mhc Class I H-2Kb molecule complexed with pKB1 peptide'''<br /> | ||
==Overview== | ==Overview== | ||
The elongated complementary-determining region (CDR) 3beta found in the | The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR and an octapeptide bound to the allogeneic H-2K(b) MHC class I molecule. This structure reveals how a tremendously large CDR3beta conformational change allows the KB5-C20 TCR to adapt to the rather constrained pMHC surface and achieve a diagonal docking mode. This extreme case of induced fit also shows that TCR plasticity is primarily restricted to CDR3 loops and does not propagate away from the antigen binding site. | ||
==About this Structure== | ==About this Structure== | ||
1KJ3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | 1KJ3 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJ3 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Darnault, C.]] | [[Category: Darnault, C.]] | ||
[[Category: Fontecilla-Camps, J | [[Category: Fontecilla-Camps, J C.]] | ||
[[Category: Gregoire, C.]] | [[Category: Gregoire, C.]] | ||
[[Category: Guimezanes, A.]] | [[Category: Guimezanes, A.]] | ||
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[[Category: Mazza, G.]] | [[Category: Mazza, G.]] | ||
[[Category: Mosser, T.]] | [[Category: Mosser, T.]] | ||
[[Category: Reiser, J | [[Category: Reiser, J B.]] | ||
[[Category: Schmitt-Verhulst, A | [[Category: Schmitt-Verhulst, A M.]] | ||
[[Category: allogeneic]] | [[Category: allogeneic]] | ||
[[Category: h-2kb]] | [[Category: h-2kb]] | ||
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[[Category: pmhc complex]] | [[Category: pmhc complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:34:42 2008'' | ||
