1ko6: Difference between revisions

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[[Image:1ko6.gif|left|200px]]<br />

[[Image:1ko6.gif|left|200px]]<br /><applet load="1ko6" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ko6" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ko6, resolution 3.00Å" />

'''Crystal Structure of C-terminal Autoproteolytic Domain of Nucleoporin Nup98'''<br />

==Overview==

Nup98 is a component of the nuclear pore that plays its primary role in, the export of RNAs. Nup98 is expressed in two forms, derived from, alternate mRNA splicing. Both forms are processed into two peptides, through autoproteolysis mediated by the C-terminal domain of hNup98. The, three-dimensional structure of the C-terminal domain reveals a novel, protein fold, and thus a new class of autocatalytic proteases. The, structure further reveals that the suggested nucleoporin RNA binding motif, is unlikely to bind to RNA. The C terminus also contains sequences that, target hNup98 to the nuclear pore complex. Noncovalent interactions, between the C-terminal domain and the cleaved peptide tail are visible and, suggest a model for cleavage-dependent targeting of hNup98 to the nuclear, pore.

Nup98 is a component of the nuclear pore that plays its primary role in the export of RNAs. Nup98 is expressed in two forms, derived from alternate mRNA splicing. Both forms are processed into two peptides through autoproteolysis mediated by the C-terminal domain of hNup98. The three-dimensional structure of the C-terminal domain reveals a novel protein fold, and thus a new class of autocatalytic proteases. The structure further reveals that the suggested nucleoporin RNA binding motif is unlikely to bind to RNA. The C terminus also contains sequences that target hNup98 to the nuclear pore complex. Noncovalent interactions between the C-terminal domain and the cleaved peptide tail are visible and suggest a model for cleavage-dependent targeting of hNup98 to the nuclear pore.

==Disease==

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==About this Structure==

1KO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1KO6 OCA].

1KO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KO6 OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Griffis, E.R.]]

[[Category: Griffis, E R.]]

[[Category: Hennig, K.A.]]

[[Category: Hennig, K A.]]

[[Category: Hodel, A.E.]]

[[Category: Hodel, A E.]]

[[Category: Hodel, M.R.]]

[[Category: Hodel, M R.]]

[[Category: Powers, M.A.]]

[[Category: Powers, M A.]]

[[Category: Ratner, G.A.]]

[[Category: Ratner, G A.]]

[[Category: Songli, X.]]

[[Category: autoproteolysis]]

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[[Category: nucleoporin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:52:~~55 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:11 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ko6.gif|left|200px]]<br />
+[[Image:1ko6.gif|left|200px]]<br /><applet load="1ko6" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ko6" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ko6, resolution 3.00&Aring;" />
 '''Crystal Structure of C-terminal Autoproteolytic Domain of Nucleoporin Nup98'''<br />
 ==Overview==
-Nup98 is a component of the nuclear pore that plays its primary role in, the export of RNAs. Nup98 is expressed in two forms, derived from, alternate mRNA splicing. Both forms are processed into two peptides, through autoproteolysis mediated by the C-terminal domain of hNup98. The, three-dimensional structure of the C-terminal domain reveals a novel, protein fold, and thus a new class of autocatalytic proteases. The, structure further reveals that the suggested nucleoporin RNA binding motif, is unlikely to bind to RNA. The C terminus also contains sequences that, target hNup98 to the nuclear pore complex. Noncovalent interactions, between the C-terminal domain and the cleaved peptide tail are visible and, suggest a model for cleavage-dependent targeting of hNup98 to the nuclear, pore.
+Nup98 is a component of the nuclear pore that plays its primary role in the export of RNAs. Nup98 is expressed in two forms, derived from alternate mRNA splicing. Both forms are processed into two peptides through autoproteolysis mediated by the C-terminal domain of hNup98. The three-dimensional structure of the C-terminal domain reveals a novel protein fold, and thus a new class of autocatalytic proteases. The structure further reveals that the suggested nucleoporin RNA binding motif is unlikely to bind to RNA. The C terminus also contains sequences that target hNup98 to the nuclear pore complex. Noncovalent interactions between the C-terminal domain and the cleaved peptide tail are visible and suggest a model for cleavage-dependent targeting of hNup98 to the nuclear pore.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-KO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KO6 OCA].
+KO6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KO6 OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Griffis, E.R.]]
+[[Category: Griffis, E R.]]
-[[Category: Hennig, K.A.]]
+[[Category: Hennig, K A.]]
-[[Category: Hodel, A.E.]]
+[[Category: Hodel, A E.]]
-[[Category: Hodel, M.R.]]
+[[Category: Hodel, M R.]]
-[[Category: Powers, M.A.]]
+[[Category: Powers, M A.]]
-[[Category: Ratner, G.A.]]
+[[Category: Ratner, G A.]]
 [[Category: Songli, X.]]
 [[Category: autoproteolysis]]
@@ Line 28: / Line 27: @@
 [[Category: nucleoporin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:52:55 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:11 2008''